Endothelial to Mesenchymal Transition in Pulmonary Vascular Diseases
نویسندگان
چکیده
منابع مشابه
Endothelial-to-mesenchymal transition in pulmonary hypertension.
BACKGROUND The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. METHODS AND RESULTS In situ evidence of EndoMT in hu...
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All forms of pulmonary hypertension are characterized by structural changes in pulmonary arteries. Increased numbers of cells expressing alpha-smooth muscle (alpha-SM) actin is a nearly universal finding in the remodeled artery. Traditionally, it was assumed that resident smooth muscle cells were the exclusive source of these newly appearing alpha-SM actin-expressing cells. However, rapidly eme...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2020
ISSN: 2227-9059
DOI: 10.3390/biomedicines8120639